Alternatively, an injection vial may be constituted, then the resulting solution added to an I. container and further diluted with an appropriate infusion fluid. Stability in Infusion Vials: Meropenem infusion vials constituted with Sodium Chloride Injection 0.9% (Meropenem concentrations ranging from 2.5 to 50 mg/m L) are stable for up to 2 hours at controlled room temperature 15-25°C (59-77°F) or for up to 18 hours at 4°C (39°F). CAPS is one of the largest national sterile injectable compounders with both 503A and 503B-registered facilities.
(See table below.) Shake to dissolve and let stand until clear.
Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Use in Adults with Renal Impairment Dosage should be reduced in patients with creatinine clearance less than 51 m L/min.
The dry powder should be stored at controlled room temperature 20-25ºC (68-77ºF) [see USP].
Stability: Meropenem injection vials constituted with sterile Water for Injection for bolus administration (up to 50 mg/m L of Meropenem) may be stored for up to 2 hours at controlled room temperature 15-25°C (59-77°F) or for up to 12 hours at 4°C (39°F). maintain satisfactory potency at controlled room temperature 15-25ºC (59-77°F) or under refrigeration at 4°C (39°F) as described below.
For Infusion Infusion vials (500 mg and 1 g) may be directly constituted with a compatible infusion fluid.